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Entry ID	Original Release date	Data summary	Entry Title	Citation Title	Authors
27835	2019-05-22	Chemical Shifts: 1 set	HRdup moPrP 118-231	Nascent beta structure in the Elongated Hydrophobic Region of a Gerstmann-Straussler-Scheinker PrP Allele	Brian D Sykes, David Westaway, Peter C Holmes, Ze-Lin Fu
30371	2018-11-06	Chemical Shifts: 1 set Spectral_peak_list: 1 set	NMR Structural and biophysical functional analysis of intracellular loop 5 of the NHE1 isoform of the Na+/H+ exchanger.	Diverse residues of intracellular loop 5 of the Na+/H+ exchanger modulate proton sensing, expression, activity and targeting	Brian D Sykes, Debajyoti Dutta, Kaitlyn Towle, Ka Yee Y Wong, Larry Fliegel, Ryan McKay, Sicheng Quan, Xiuju Li, Yesmine Elloumi, Yongsheng Liu
25810	2016-07-20	Chemical Shifts: 1 set	NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the covalent levosimendan analog i9.	Troponin C with covalently bound levosimendan analog i9 enhances contraction in cardiac muscle fibers	Brian D Sykes, Ian M Robertson, Malcolm Irving, Sandra E Pineda Sanabria, Yin-Biao Sun
25511	2016-06-30	Chemical Shifts: 1 set T1 Relaxation Values: 2 sets T2 Relaxation Values: 2 sets	Structure and dynamics of the acidosis-resistant a162H mutant of the switch region of troponin I bound to the regulatory domain of troponin C	Structure and Dynamics of the Acidosis-Resistant A162H Mutant of the Switch Region of Troponin I Bound to the Regulatory Domain of Troponin C	Brian D Sykes, Ian M Robertson, Sandra E Pineda Sanabria
25495	2015-06-01	Chemical Shifts: 1 set	Structure and dynamics of the acidosis-resistant a162H mutant of the switch region of troponin I bound to the regulatory domain of troponin C	Structure and dynamics of the acidosis-resistant A162H mutant of the switch region of troponin I bound to the regulatory domain of troponin C	Brian D Sykes, Ian M Robertson, Sandra E Pineda Sanabria
25034	2014-09-18	Chemical Shifts: 1 set Heteronuclear NOE Values: 2 sets T1 Relaxation Values: 2 sets T2 Relaxation Values: 2 sets	Amide 1H and 15N chemical shift assignments and 15N relaxation parameters of the troponin C-troponin I hybrid proteins cChimera	Versatile cardiac troponin chimera for muscle protein structural biology and drug discovery.	Brian D Sykes, Olivier Julien, Sandra E Pineda-Sanabria
25035	2014-09-18	Chemical Shifts: 1 set Heteronuclear NOE Values: 2 sets T1 Relaxation Values: 2 sets T2 Relaxation Values: 2 sets	Amide 1H and 15N chemical shift assignments and 15N relaxation parameters of the troponin C-troponin I hybrid proteins cChimeraX	Versatile cardiac troponin chimera for muscle protein structural biology and drug discovery.	Brian D Sykes, Olivier Julien, Sandra E Pineda-Sanabria
19817	2014-03-10	Chemical Shifts: 1 set	NMR structure of the dilated cardiomyopathy mutation G159D in troponin C bound to the anchoring region of troponin I	The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I.	Brian D Sykes, Ian M Robertson, Olga K Baryshnikova, Pascal Mercier
19816	2014-03-10	Chemical Shifts: 1 set	NMR structure of the C-domain of troponin C bound to the anchoring region of troponin I	The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I.	Brian D Sykes, Ian M Robertson, Olga K Baryshnikova, Pascal Mercier
19789	2014-02-11	Chemical Shifts: 2 sets	N domain of cardiac troponin C bound to the switch fragment of fast skeletal troponin I at pH 6	Conformation of the critical pH sensitive region of troponin depends upon a single residue in troponin I.	Brian D Sykes, Ian M Robertson, Peter C Holmes, Sandra E Pineda-Sanabria
19484	2014-06-30	Chemical Shifts: 1 set	NMR structure of a two-transmembrane segment TM VI-VII of NHE1	Structural and Functional Analysis of the Transmembrane Segment Pair VI and VII of the NHE1 Isoform of the Na(+)/H(+) Exchanger	Brian D Sykes, Brian L Lee, Claudia Alves, Larry Fliegel
19216	2013-06-04	Chemical Shifts: 1 set	Structural and Functional Analysis of Transmembrane Segment IV of the Salt Tolerance Protein Sod2	Structural and Functional Analysis of Transmembrane Segment IV of the Salt Tolerance Protein Sod2.	Asad Ullah, Brian D Sykes, Brian Lee, Claudia Alves, Grant Kemp, Howard Young, Larry Fliegel
17440	2011-02-24	Chemical Shifts: 1 set	Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C	Structure of trans-Resveratrol in Complex with the Cardiac Regulatory Protein Troponin C.	Brian D Sykes, Ian M Robertson, Sandra E Pineda-Sanabria
17422	2011-02-09	Chemical Shifts: 1 set	Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir	Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir.	Brian D Sykes, David H Evans, James R Beadle, Karl Y Hostetler, Olivier Julien, Subhrangsu Chatterjee, Wendy C Magee
17423	2011-02-09	Chemical Shifts: 1 set	Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir	Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir.	Brian D Sykes, David H Evans, James R Beadle, Karl Y Hostetler, Olivier Julien, Subhrangsu Chatterjee, Wendy C Magee
17243	2011-06-01	Chemical Shifts: 1 set	The Solution Structure of Human Cardiac Troponin C in complex with the Green Tea Polyphenol; (-)-epigallocatechin-3-gallate	Solution structure of human cardiac troponin C in complex with the green tea polyphenol, (-)-epigallocatechin 3-gallate.	Brian D Sykes, Ian M Robertson, Monica X Li
17103	2010-09-08	Chemical Shifts: 1 set	The structure of the calcium-sensitizer, dfbp-o, in complex with the N-domain of troponin C and the switch region of troponin I	A structural and functional perspective into the mechanism of Ca(2+)-sensitizers that target the cardiac troponin complex.	Brian D Sykes, Ian M Robertson, Monica X Li, Yin-Biao Sun
17040	2010-09-03	Chemical Shifts: 1 set	STRUCTURAL AND FUNCTIONAL ANALYSIS OF TM VI OF THE NHE1 ISOFORM OF THE Na+/H+ EXCHANGER	Structural and Functional Analysis of Transmembrane Segment VI of the NHE1 Isoform of the Na+/H+ Exchanger.	Brian D Sykes, Brian L Lee, Jennifer Tzeng, Larry Fliegel
16752	2010-03-24	Binding_constants: 1 set	Mapping the Interacting Regions between Troponins T and C	Mapping the Interacting Regions between Troponins T and C	Brian D Sykes, Brian P Tripet, Robert S Hodges, Tharin MA Blumenschein
16414	2010-03-05	Binding_constants: 1 set	Interaction of the Second Binding Region Troponin I with the Regulatory Domain of Skeletal Muscle Troponin C as Determined by NMR Spectroscopy	Interaction of the Second Binding Region of Troponin I with the Regulatory Domain of Skeletal Muscle Troponin C as Determined by NMR Spectroscopy	Brian D Sykes, Brian P Tripet, Robert S Hodges, Ryan T McKay
16190	2009-05-20	Chemical Shifts: 1 set	Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7	Structure of the inhibitor w7 bound to the regulatory domain of cardiac troponin C	Brian D Sykes, Ryan MB Hoffman
16056	2009-01-21	Chemical Shifts: 1 set	STRUCTURAL AND FUNCTIONAL ANALYSIS OF TM XI OF THE NHE1 ISOFORM OF THE NA+/H+ EXCHANGER	Structural and Functional Analysis of TM XI of the NHE1 Isoform of the Na+/H+ Exchanger	Brian D Sykes, Brian L Lee, Larry Fliegel, Xiuju Li, Yongsheng Liu
15747	2008-05-29	Chemical Shifts: 1 set	Structural and Functional Characterization of TM IX of the NHE1 Isoform of the Na+/H+ Exchanger	Structural and Functional Characterization of TM IX of the NHE1 Isoform of the Na+/H+ Exchanger	Brian D Sykes, Jan K Rainey, J Ding, Larry Fliegel, Tyler Reddy, X Li
7245	2006-08-12	Chemical Shifts: 1 set	Structural and Functional Characterization of TM VII of the NHE1 Isoform of the Na+/H+ Exchanger	Structural and functional characterization of transmembrane segment VII of the Na+/H+ exchanger isoform 1.	Brian D Sykes, Carolyn Xu, Jan K Rainey, Jie Ding, Larry Fliegel
6260	2004-07-26	Chemical Shifts: 2 sets	NMR solution Structure of a Highly Stable de novo Heterodimeric Coiled-Coil	NMR solution Structure of a Highly Stable de novo Heterodimeric Coiled-Coil	Brian D Sykes, Darrin A Lindhout, Jennifer R Litowski, Pascal Mercier, Robert S Hodges
5975	2003-12-08	Chemical Shifts: 2 sets	1H and 15N chemical shift assignments for the N-domain of trout cardiac troponin C at 30 and 7 C	Effect of temperature and the F27W mutation on the Ca2+ activated structural transition of trout cardiac troponin C	Brian D Sykes, Glen F Tibbits, Tharin M A Blumenschein, Todd E Gillis
5572	2002-12-27	Chemical Shifts: 1 set	Beta-helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect	Beta-helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect	Brian D Sykes, Michael J Kuiper, Peter L Davies, Steffen P Graether, Stephane M Gagne, Virginia K Walker, Zongchao Jia
5573	2003-05-14	Chemical Shifts: 1 set	Spruce budworm Antifreeze Protein: Changes in Structure and Dynamics at Low Temperature	Spruce Budworm Antifreeze Protein: Changes in Structure and Dynamics at Low Temperature	Brian D Sykes, Leo Spyracopoulos, Peter L Davies, Steffen P Graether, Stephane M Gagne, Zongchao Jia
5386	2003-02-25	Chemical Shifts: 2 sets Coupling Constants: 1 set	1H, 13C, 15N Chemical Shift Assignments of cNTnC and cTnI(147-163) in the cNTnC-cTnI(147-163)-Bepridil Ternary complex	Structure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac Troponin I147-163 and Bepridil	Brian D Sykes, Monica X Li, Xu Wang
5383	2003-01-06	Chemical Shifts: 1 set	The CXCR3 binding chemokine IP-10/CXCL10: Structure and receptor interactions	The CXCR3 Binding Chemokine IP-10/CXCL10: Structure and Receptor Interactions	Brian D Sykes, David W Keizer, Ian Clark-Lewis, Monique B Kamphuis, Valerie Booth
4994	2010-01-06	Chemical Shifts: 2 sets Coupling Constants: 1 set	Structure of the C-domain of Human Cardiac Troponin C in Complex with the Ca2+ Sensitizing Drug EMD 57033	Structure of the C-domain of Human Cardiac Troponin C in Complex with the Ca2+ Sensitizing drug EMD 57033	Brian D Sykes, Leo Spyracopoulos, Monica X Li, Murali Chandra, Norbert Beier, R John Solaro, Xu Wang
4914	2001-01-23	Chemical Shifts: 1 set	Backbone 1H chemical shift assignments for vMIP-II	Structure/Function of Human Herpesvirus-8 MIP-II (1-71) and the Antagonist N-terminal Segment (1-10)	Brian D Sykes, Elena Elisseeva, Ian Clark-Lewis, Jiang-Hong Gong, Matthew P Crump
4918	2001-01-04	Chemical Shifts: 1 set Coupling Constants: 1 set	Letter to the Editor: Assignments of 1H and 15N resonances of the Pseudomonas aeruginosa K122-4 pilin monomer.	Letter to the Editor: Assignments of 1H and 15N resonances of the Pseudomonas aeruginosa K122-4 pilin monomer	Brian D Sykes, David W Keizer, Jeong-Yong Suh, Matthew P Crump, Michal Kalsiak, Randall T Irvin
4836	2003-01-13	Chemical Shifts: 1 set	Complete 1H, 13C and 15N Backbone Assignments for the Hepatitis A Virus 3C Protease	Letter to the Editor: Complete 1H, 13C and 15N backbone assignments for the hepatitis A virus 3C protease	Brian D Sykes, Carolyn M Slupsky, David S Wishart, Leo Spyracopoulos, M Scott Watson, Trent C Bjorndahl
4686	2000-06-16	Chemical Shifts: 1 set Coupling Constants: 1 set	The Human CC Chemokine I-309, Structural Consequences of the Additional Disulfide Bond.	Human CC Chemokine I-309, Structural Consequences of the Additional Disulfide Bond.	Brian D Sykes, Carolyn M Slupsky, David W Keizer, Ian Clark-Lewis, Matthew P Crump, Tae Woo Lee
4232	1999-05-25	Chemical Shifts: 2 sets Coupling Constants: 1 set	N-Domain of Troponin C from Chicken Skeletal Muscle.	Low Temperature-Induced Structural Changes in the Apo Regulatory Domain of Skeletal Muscle Troponin C	A Miura, Brian D Sykes, L Spyracopoulos, Sakae Tsuda, S M Gagne
4080	2001-02-17	Chemical Shifts: 1 set	NMR Solution Structure of Calcium-Saturated Skeletal Muscle Troponin C	NMR Solution Structure of Calcium-Saturated Skeletal Muscle Troponin C	Brian D Sykes, Carolyn M Slupsky
290	1999-06-14	Chemical Shifts: 1 set	A 1H NMR Determination of the Solution Conformation of a Synthetic Peptide Analogue of Calcium-Binding Site III of Rabbit Skeletal Troponin C	A 1H NMR Determination of the Solution Conformation of a Synthetic Peptide Analogue of Calcium-Binding Site III of Rabbit Skeletal Troponin C	Brian D Sykes, Brian J Marsden, Robert S Hodges
862	1995-07-31	Chemical Shifts: 1 set	Hydrogen-1 Nuclear Magnetic Resonance Investigation of Bovine Cardiac Troponin C. Comparison of Tyrosyl Assignments and Calcium-Induced Structural Changes to Those of Two Homologous Proteins, Rabbit Skeletal Troponin C and Bovine Brain Calm	Hydrogen-1 Nuclear Magnetic Resonance Investigation of Bovine Cardiac Troponin C. Comparison of Tyrosyl Assignments and Calcium-Induced Structural Changes to Those of Two Homologous Proteins, Rabbit Skeletal Troponin C and Bovine Brain Calm	Brian D Sykes, Cyril M Kay, Maxwell T Hincke
2117	1999-06-14	Chemical Shifts: 1 set	Interaction of Troponin I and Troponin C (Use of the Two-dimensional Nuclear Magnetic Resonance Transferred Nuclear Overhauser Effect to Determine the Structure of the Inhibitory Troponin I Peptide when Bound to Skeletal Troponin C)	Interaction of Troponin I and Troponin C (Use of the Two-dimensional Nuclear Magnetic Resonance Transferred Nuclear Overhauser Effect to Determine the Structure of the Inhibitory Troponin I Peptide when Bound to Skeletal Troponin C)	A Patricia Campbell, Brian D Sykes
3118	1995-07-31	Chemical Shifts: 1 set	Stoichiometry of Calcium Binding to a Synthetic Heterodimeric Troponin-C Domain	Stoichiometry of Calcium Binding to a Synthetic Heterodimeric Troponin-C Domain	Brian D Sykes, Gary S Shaw, Robert S Hodges
1039	1995-07-31	Chemical Shifts: 1 set	Complete Tyrosine Assignments in the High Field 1H Nuclear Magnetic Resonance Spectrum of the Bovine Pancreatic Trypsin Inhibitor	Complete Tyrosine Assignments in the High Field 1H Nuclear Magnetic Resonance Spectrum of the Bovine Pancreatic Trypsin Inhibitor	Brian D Sykes, Grayson H Snyder, Robert III, Susan Karplus
1227	1999-06-14	Chemical Shifts: 1 set	Nuclear Magnetic Resonance Studied of a Ca2+-Binding Fragment of Troponin C.	Nuclear Magnetic Resonance Studied of a Ca2+-Binding Fragment of Troponin C.	Brian D Sykes, Edward R Birnbaum
2763	1999-06-14	Chemical Shifts: 1 set	Comparison of the Structure and Dynamics of Chicken Gizzard and Rabbit Cardiac Tropomyosins: 1H NMR Spectroscopy and Measurement of Amide Hydrogen Exchange Rates	Comparison of the Structure and Dynamics of Chicken Gizzard and Rabbit Cardiac Tropomyosins: 1H NMR Spectroscopy and Measurement of Amide Hydrogen Exchange Rates	Brian D Sykes, Clive Sanders, Lawrence B Smillie
1222	1999-06-14	Chemical Shifts: 1 set	Laser Photochemically Induced Dynamic Nuclear Polarization Proton Nuclear Magnetic Resonance Studies on Three Homologous Calcium Binding Proteins: Cardiac Troponin-C, Skeletal Troponin-C, and Calmodulin	Laser Photochemically Induced Dynamic Nuclear Polarization Proton Nuclear Magnetic Resonance Studies on Three Homologous Calcium Binding Proteins: Cardiac Troponin-C, Skeletal Troponin-C, and Calmodulin	Brian D Sykes, Cyril M Kay, Maxwell T Hincke
3036	1999-06-14	Chemical Shifts: 1 set	Effect of Trifluoroethanol on Protein Secondary Structure: An NMR and CD Study Using a Synthetic Actin Peptide	Effect of Trifluoroethanol on Protein Secondary Structure: An NMR and CD Study Using a Synthetic Actin Peptide	Brian D Sykes, F D Sonnichsen, Jennifer Van Eyk, Robert S Hodges
1228	1999-06-14	Chemical Shifts: 1 set	Nuclear Magnetic Resonance Studied of a Ca2+-Binding Fragment of Troponin C.	Nuclear Magnetic Resonance Studied of a Ca2+-Binding Fragment of Troponin C.	Brian D Sykes, Edward R Birnbaum
3119	1999-06-14	Chemical Shifts: 1 set	Stoichiometry of Calcium Binding to a Synthetic Heterodimeric Troponin-C Domain	Stoichiometry of Calcium Binding to a Synthetic Heterodimeric Troponin-C Domain	Brian D Sykes, Gary S Shaw, Robert S Hodges
3127	1999-06-14	Chemical Shifts: 1 set	Proton Nuclear Magnetic Resonance Studies of Porcine Intestinal Calcium Binding Protein	Proton Nuclear Magnetic Resonance Studies of Porcine Intestinal Calcium Binding Protein	Brian D Sykes, Joe DJ O'Neil, Judith G Shelling, Theo Hofmann
3128	1999-06-14	Chemical Shifts: 1 set	Proton Nuclear Magnetic Resonance Studies of Porcine Intestinal Calcium Binding Protein	Proton Nuclear Magnetic Resonance Studies of Porcine Intestinal Calcium Binding Protein	Brian D Sykes, Joe DJ O'Neil, Judith G Shelling, Theo Hofmann
3404	2008-03-24	Chemical Shifts: 1 set	A Single-Stranded Amphiphatic alpha-Helix in Aqueous Solution: Design, Structural Characterization, and Its Application for Determining alpha-Helical Propensities of Amino Acids	A Single-Stranded Amphiphatic alpha-Helix in Aqueous Solution: Design, Structural Characterization, and Its Application for Determining alpha-Helical Propensities of Amino Acids	Brian D Sykes, Cyril M Kay, Nian E Zhou, Robert S Hodges
846	1995-07-31	Chemical Shifts: 1 set	Hydrogen-1 Nuclear Magnetic Resonance Investigation of Bovine Cardiac Troponin C. Comparison of Tyrosyl Assignments and Calcium-Induced Structural Changes to Those of Two Homologous Proteins, Rabbit Skeletal Troponin C and Bovine Brain Calm	Hydrogen-1 Nuclear Magnetic Resonance Investigation of Bovine Cardiac Troponin C. Comparison of Tyrosyl Assignments and Calcium-Induced Structural Changes to Those of Two Homologous Proteins, Rabbit Skeletal Troponin C and Bovine Brain Calm	Brian D Sykes, Cyril M Kay, Maxwell T Hincke
2116	1999-06-14	Chemical Shifts: 1 set	Interaction of Troponin I and Troponin C (Use of the Two-dimensional Nuclear Magnetic Resonance Transferred Nuclear Overhauser Effect to Determine the Structure of the Inhibitory Troponin I Peptide when Bound to Skeletal Troponin C)	Interaction of Troponin I and Troponin C (Use of the Two-dimensional Nuclear Magnetic Resonance Transferred Nuclear Overhauser Effect to Determine the Structure of the Inhibitory Troponin I Peptide when Bound to Skeletal Troponin C)	A Patricia Campbell, Brian D Sykes