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Entry ID	Original Release date	Data summary	Entry Title	Citation Title	Authors
52600	2025-03-06	Chemical Shifts: 1 set	chemical shift assignments of a De novo design of protein that bind naphthalenediimides	De Novo Design of Proteins That Bind Naphthalenediimides, Powerful Photooxidants with Tunable Photophysical Properties	Ian Bakanas, James A Wells, Jarrett P Mansergh, Jiaqi Zhu, Mark Kelly, Michael J Therien, Rui Liu, Samuel I Mann, Sophia K Tan, William F DeGrado, Yibing Wu, Zachary Widel, Zhi Lin
52369	2024-12-26	Chemical Shifts: 1 set	TDP-43 W334G/W385G/W412G	TDP-43 Amyloid Fibril Formation via Phase Separation-Related and -Unrelated Pathways	Guan-Wei W Wu, Jie-Rong R Huang, Jing-Rou R Huang, Pin-Han H Lin, U-Ser S Jeng, Wei-Min M Liu, Yu-Hao H Lin
51659	2022-11-03	Chemical Shifts: 1 set	Backbone Chemical Shift Assignments of human glutathione peroxidase 4 (GPx4)	Small-molecule allosteric inhibitors of GPX4	Annie J Lin, Brent R Stockwell, Farhad Forouhar, Hengrui Liu, Qian Wang, Rajesh K Soni, Vasiliki Polychronidou, Xin Xin
51151	2024-08-09	Chemical Shifts: 1 set	OmpR	Promiscuity of response regulators for thioredoxin steers bacterial virulence	Alexandra Born, Andres Vasquez-Torres, Beat Vogeli, James Till, Ju-Sim Kim, Lin Liu, Morkos Henen, Sashi Kant
51150	2024-08-09	Chemical Shifts: 1 set	Apo Thioredoxin	Promiscuity of response regulators for thioredoxin steers bacterial virulence	Alexandra Born, Andres Vazquez-Torres, Beat Vogeli, James Till, Ju-Sim Kim, Lin Liu, Morkos Henen, Sashi Kent
50592	2021-06-30	Chemical Shifts: 1 set	Slow disulfide bridge formation in the folded CH2 domain	The reduced form of the antibody CH2 domain.	Dimiter S Dimitrov, John D Persons, Rieko Ishima, Rui Lin, Tatiana V Ilina, Wei Li, Xianglei Liu, Zhaoyong Xi
50544	2020-12-02	Chemical Shifts: 1 set	1H, 13C, 15N backbone and side-chain resonance assignments of the G131V pathogenic mutant of human prion protein	1H, 13C, 15N backbone and side-chain resonance assignments of the pathogenic G131V mutant of human prion protein (91-231)	Chenyun Guo, Donghai Lin, Fengyu Zheng, Haoran Zhang, Qiaodong Zhang, Rong Liu, Xinli Liao
50525	2021-10-22	Chemical Shifts: 1 set	transmembrane domain of PD-L1	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain	Bin Wu, Bo OuYang, Chenqi Xu, Hongjuan Xue, Jialing Lin, Jie Xu, Maorong Wen, Qian Wang, Ruiyu Cao, Taoran Xiao, Xiwei Liu, Yang Yu, Yunlei Cao
50443	2021-04-16	Chemical Shifts: 1 set	1H, 13C, and 15N resonance assignments of reduced apo-WhiB4 from Mycobacterium tuberculosis	1H, 13C, and 15N resonance assignments of reduced apo-WhiB4 from Mycobacterium tuberculosis	Bin Xia, Bo Duan, Chen Lin, Jun Liu, Lu Zhang, Qiran Zhai
50199	2020-02-19	Chemical Shifts: 1 set	1H, 15N Resonance Assignments of VAMP2(1-96) in HEK-293T Cells	Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly	Bin Cai, Chuchu Wang, Cong Liu, Dan Li, Guohui Li, Jiajie Diao, Jia Tu, Lin He, Qinglu Zhong, Shengnan Zhang, Shouqiao Hou, Wenbin Liu, Xiao Hu, Zheng-Jiang Zhu, Zhenying Liu, Zhijun Liu
50198	2020-02-19	Chemical Shifts: 1 set	1H, 15N Resonance Assignments of VAMP2(1-96) in SH-SY5Y Cells	Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly	Bin Cai, Chuchu Wang, Cong Liu, Dan Li, Guohui Li, Jiajie Diao, Jia Tu, Lin He, Qinglu Zhong, Shengnan Zhang, Shouqiao Hou, Wenbin Liu, Xiao Hu, Zheng-Jiang Zhu, Zhenying Liu, Zhijun Liu
30707	2020-08-14	Chemical Shifts: 1 set	De novo designed Rossmann fold protein ROS2_835	Expanding the space of protein geometries by computational design of de novo fold families	James S Fraser, Lin Liu, Mark Kelly, Michael C Thompson, Tanja Kortemme, Xingjie Pan, Yang Zhang
30706	2020-08-14	Chemical Shifts: 1 set	De novo designed Rossmann fold protein ROS2_49223	Expanding the space of protein geometries by computational design of de novo fold families	James S Fraser, Lin Liu, Mark Kelly, Michael C Thompson, Tanja Kortemme, Xingjie Pan, Yang Zhang
30708	2020-08-14	Chemical Shifts: 1 set	De novo designed Rossmann fold protein ROS2_36830	Expanding the space of protein geometries by computational design of de novo fold families	James S Fraser, Lin Liu, Mark Kelly, Michael C Thompson, Tanja Kortemme, Xingjie Pan, Yang Zhang
36293	2021-08-02	Chemical Shifts: 1 set	membrane-bound PD-L1-CD	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain	Bin Wu, Bo OuYang, Chenqi Xu, Hongjuan Xue, Jialing Lin, Jie Xu, Maorong Wen, Qian Wang, Ruiyu Cao, Taoran Xiao, Xiwei Liu, Yang Yu, Yunlei Cao
36294	2021-05-11	Chemical Shifts: 1 set	membrane-bound Bax helix2-helix5 domain	An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane	Alessandro Piai, Bin Wu, Bo OuYang, David W Andrews, Fei Qi, Fujiao Lv, James J Chou, Jialing Lin, Juan Del Rosario, Justin Kale, Justin Pogmore, Lingyu Du, Liujuan Zhou, Maorong Wen, Shuqing Wang, Yaqing Yang, Zhijun Liu, Zhi Zhang
50035	2021-06-13	Chemical Shifts: 1 set	Backbone 1H, 13C, and 15N Chemical Shift Assignments for dL3D1	Backbone 1H, 13C, and 15N Chemical Shift Assignments for dL3D1	Chuchu Wang, Chunyu Jia, Chunyu Zhao, Cong Liu, Dan Li, Enquan Xu, Guoqin Feng, Houfang Long, Jin-Jian Hu, Lin Jiang, Mengrong Ma, Renxiao Wang, Shengnan Zhang, Ted M Dawson, Valina L Dawson, Xiaobo Mao, Yan-Mei Li, Yasuyoshi Kimura, Yeh-Jun Lim, Youqi Tao, Yuqing Liu, Zhenying Liu
50034	2021-06-13	Chemical Shifts: 1 set	Backbone 1H, 13C, and 15N Chemical Shift Assignments for APLP1 E1 domain	Backbone 1H, 13C, and 15N Chemical Shift Assignments for APLP1 E1 domain	Chuchu Wang, Chunyu Jia, Chunyu Zhao, Cong Liu, Dan Li, Enquan Xu, Guoqin Feng, Houfang Long, Jin-Jian Hu, Lin Jiang, Mengrong Ma, Renxiao Wang, Shengnan Zhang, Ted M Dawson, Valina L Dawson, Xiaobo Mao, Yan-Mei Li, Yasuyoshi Kimura, Yeh-Jun Lim, Youqi Tao, Yuqing Liu, Zhenying Liu
36243	2023-02-23	Chemical Shifts: 1 set	Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR	The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis.	Bing Li, Charles D Schwieters, Guo-Xiang X Wu, Hong Hu, Hua-Yi Y Wang, Jian Wang, Jing X Liu, Jing-Yu Y Lin, Jing Zhang, Jun-Xia X Lu, Xia-Lian L Wu, Xing-Qi Q Dong
27830	2019-04-11	Chemical Shifts: 1 set	Backbone 1H, 13C and 15N Chemical Shift Assignment of complex of MarH with L-Trp	Structural basis of the mechanism of beta-methyl epimerization by enzyme MarH	Bin Liu, Kaifeng Hu, Rundong Zhang, Shiqi Fang, Shuangjun Lin, Tao Huang, Xiaofang Ma, Xiaozheng Wang, Yan Hou, Yanli Chen, Zhiqiang Bai
30577	2019-10-18	Chemical Shifts: 1 set	NMR structure of the 2:1 complex of a carbazole derivative BMVC bound to c-MYC G-quadruplex	Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition	Clement Lin, Danzhou Yang, Guanhui Wu, Jixun Dai, Ta-Chau C Chang, Wenting Liu
27576	2018-09-12	Chemical Shifts: 1 set	Backbone 1H, 13C, and 15N Chemical Shift Assignments for A97S TTR in 5% DMSO	Biophysical characterization and modulation of Transthyretin Ala97Ser	Frans Ricardo, Kon-Ping P Lin, Pei-Hao H Wu, Shing-Jong J Huang, Tsyr-Yan Y Yu, Yo-Tsen T Liu, Yu Chang, Yueh-Jung J Yen
27575	2018-09-12	Chemical Shifts: 1 set	Backbone 1H, 13C, and 15N Chemical Shift Assignments for transthyetin in 5% DMSO	Biophysical characterization and modulation of Transthyretin Ala97Ser	Frans Ricardo, Kon-Ping P Lin, Pei-Hao H Wu, Shing-Jong J Huang, Tsyr-Yan Y Yu, Yo-Tsen T Liu, Yu Chang, Yueh-Jung J Yen
30373	2017-12-06	Chemical Shifts: 1 set Spectral_peak_list: 1 set	Solution NMR structures of BRD4 ET domain with JMJD6 peptide	Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer	Binhua P Zhou, B Mark M Evers, Chi Wang, Fang Tai, Jian Shi, Jingyi Liu, Jiong Deng, Lei Zeng, Ming-Ming M Zhou, Pengnian Charles C Lin, Qiang Zhang, Rachel L Stewart, Saghi Ghaffari, Suling Liu, Weijie Guo, Yadi Wu, Yanling He, Yifan Wang, Yiwei Lin, Yule Chen, Zhibing Duan
27217	2018-04-18	Chemical Shifts: 2 sets	Backbone Chemical Shift Assignments for the S99T/C115S Mutant of Human Cyclophilin A	Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution	Dan S Tawfik, David Mavor, Dorothee Kern, James S Fraser, Lillian R Kenner, Lin Liu, Michael W Clarkson, Renee Otten
27218	2018-04-18	Chemical Shifts: 2 sets	Backbone Chemical Shift Assignments for the S99T/C115S/I97V Mutant of Human Cyclophilin A	Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution	Dan S Tawfik, David Mavor, Dorothee Kern, James S Fraser, Lillian R Kenner, Lin Liu, Michael W Clarkson, Renee Otten
26985	2017-04-26	Chemical Shifts: 1 set	1H, 13C and 15N resonance assignments of SmpB from Mycobacterium tuberculosis	Backbone and side-chain resonance assignments for the tmRNA-binding protein, SmpB, from Mycobacterium tuberculosis	Chun Meng, Donghai Lin, Juanjuan Yang, Yindi Liu, Zhao Liu
25794	2016-01-25	Residual Dipolar Couplings: 2 sets	Solution NMR Structure of DE NOVO DESIGNED PROTEIN, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446	Solution NMR Structure of DE NOVO DESIGNED PROTEIN, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446	David Baker, Gaetano T Montelione, Gaohua Liu, Gregory Kornhaber, Haleema Janjua, John K Everett, Kari Pederson, Nobuyasu Koga, Rie Koga, Rong Xiao, Thomas B Acton, Yu-Ru Lin
25662	2015-09-14	Chemical Shifts: 1 set Residual Dipolar Couplings: 2 sets Spectral_peak_list: 2 sets	Solution NMR Structure of DE NOVO DESIGNED PROTEIN, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446	Solution NMR Structure of DE NOVO DESIGNED PROTEIN, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446	David Baker, Gaetano T Montelione, Gaohua Liu, Gregory Kornhaber, Haleema Janjua, John K Everett, Kari Pederson, Nobuyasu Koga, Rie Koga, Rong Xiao, Thomas B Acton, Yu-Ru Lin
25611	2015-09-14	Chemical Shifts: 1 set Spectral_peak_list: 2 sets	Solution NMR Structure of DE NOVO DESIGNED PROTEIN (FDA_60), Northeast Structural Genomics Consortium (NESG) Target OR303	Solution NMR Structure of DE NOVO DESIGNED PROTEIN (FDA_60), Northeast Structural Genomics Consortium (NESG) Target OR303	David Baker, Gaetano T Montelione, Gaohua Liu, Gregory Kornhaber, Haleema Janjua, John K Everett, Keith Hamilton, Nobuyasu Koga, Rie Koga, Rong Xiao, Thomas B Acton, Yu-Ru Lin
25612	2015-09-14	Chemical Shifts: 1 set Residual Dipolar Couplings: 1 set Spectral_peak_list: 2 sets	Solution NMR Structure of DE NOVO DESIGNED Ferredoxin Fold PROTEIN sfr3, Northeast Structural Genomics Consortium (NESG) Target OR358	Solution NMR Structure of DE NOVO DESIGNED Ferredoxin Fold PROTEIN sfr3, Northeast Structural Genomics Consortium (NESG) Target OR358	David Baker, Gaetano T Montelione, Gaohua Liu, Gregory Kornhaber, Haleema Janjua, John K Everett, Kari Pederson, Keith Hamilton, Nobuyasu Koga, Rie Koga, Rong Xiao, Thomas B Acton, Yu-Ru Lin
25453	2015-08-13	Chemical Shifts: 1 set	1H, 13C and 15N assignment of the C-terminal domain of human galectin 8	NMR assignments of the C-terminal domain of human galectin-8	Chih-Ta Henry Chien, Chun-Hao Gerard Liu, Chun-Hung Lin, Shang-Te Danny Hsu
25423	2015-11-09	Chemical Shifts: 1 set	Solution structure of NDP52 ubiquitin-binding zinc finger	Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2	Jianping Liu, Lifeng Pan, Xiaofang Chen, Xingqiao Xie, Yingli Wang, Zhijie Lin
25018	2014-08-25	Chemical Shifts: 1 set Residual Dipolar Couplings: 1 set Spectral_peak_list: 3 sets	Solution NMR Structure of DE NOVO DESIGNED PROTEIN LFR1 WITH FERREDOXIN FOLD, Northeast Structural Genomics Consortium (NESG) Target OR414	Solution NMR Structure of DE NOVO DESIGNED PROTEIN LFR1 1WITH FERREDOXIN FOLD, Northeast Structural Genomics Consortium (NESG) Target OR414	David Baker, Gaetano T Montelione, Gaohua Liu, Gregory Kornhaber, Haleema Janjua, John K Everett, Kari Pederson, Nobuyasu Koga, Rie Koga, Rong Xiao, Thomas B Acton, Yu-Ru Lin
19696	2014-03-31	Chemical Shifts: 1 set	Nuclear magnetic resonance studies of N2-guanine adducts derived from the tumorigen dibenzo[a,l]pyrene in DNA: Impact of adduct stereochemistry, size, and local DNA structure on solution conformations	Nuclear Magnetic Resonance Studies of an N(2)-Guanine Adduct Derived from the Tumorigen Dibenzo[a,l]pyrene in DNA: Impact of Adduct Stereochemistry, Size, and Local DNA Sequence on Solution Conformations	Alexander Kolbanovskiy, Chin H Lin, Fabian A Rodriguez, Marina Kolbanovskiy, Nicholas E Geacintov, Shantu Amin, Shuang Ding, Suse Broyde, Yuqin Cai, Zhi Liu
19695	2014-03-31	Chemical Shifts: 1 set	NMR studies of N2-guanine adducts derived from the tumorigen dibenzo[a,l]pyrene in DNA: Impact of adduct stereochemistry, size, and local DNA structure on solution conformations	Nuclear Magnetic Resonance Studies of an N(2)-Guanine Adduct Derived from the Tumorigen Dibenzo[a,l]pyrene in DNA: Impact of Adduct Stereochemistry, Size, and Local DNA Sequence on Solution Conformations	Alexander Kolbanovskiy, Chin H Lin, Fabian A Rodriguez, Marina Kolbanovskiy, Nicholas E Geacintov, Shantu Amin, Shuang Ding, Suse Broyde, Yuqin Cai, Zhi Liu
19287	2013-10-14	Chemical Shifts: 1 set	Solution structure of a chymotrypsin inhibitor from the Taiwan cobra	'NMR solution structure of a Chymotrypsin inhibitor from the Taiwan cobra Naja naja atra	Long-Sen Chang, Teppei Ikeya, Ting-Hsiu Liu, Yi-Jan Lin
18762	2012-11-20	Chemical Shifts: 1 set	NMR solution structure of an N2-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: Intercalation from the minor groove with ruptured Watson-Crick base pairing	Nuclear Magnetic Resonance Solution Structure of an N(2)-Guanine DNA Adduct Derived from the Potent Tumorigen Dibenzo[a,l]pyrene: Intercalation from the Minor Groove with Ruptured Watson-Crick Base Pairing.	Chin H Lin, Donald M Jerina, Fabian A Rodriguez, Jane M Sayer, Nicholas E Geacintov, Shantu Amin, Shuang Ding, Suse Broyde, Yijin Tang, Yuqin Cai, Zhi Liu
17364	2012-06-04	Chemical Shifts: 1 set	The solution structure of the PTB Domain of TENC1 in complex with the peptide of DLC1	Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.	Changdong Liu, Frankie Chi Fat Ko, Guang Zhu, Irene Oi-Lin Ng, Judy Wai Ping Yam, Lihong Chen, Naining Xu
17279	2011-05-05	Chemical Shifts: 1 set	Solution NMR structure of protein lipocalin 12 from rat epididymis	Solution structure of the protein lipocalin 12 from rat epididymis.	Chenyun Guo, Donghai Lin, Jiafu Liu, Qiang Liu, Xu Zhang, Yonglian Zhang, Yu Peng
17258	2011-08-17	Chemical Shifts: 1 set	Resonance assignments and secondary structure of a phytocystatin from Ananas comosus	Resonance assignments and secondary structure of a phytocystatin from Ananas comosus.	Bo-Jiun Chen, Chia-Lin Chyan, Deli Irene, Jason T-C Tzen, Si-Hung Lo, Ting-Hang Liu
16874	2010-05-17	Chemical Shifts: 1 set	The solution structure of rat Lipocalin-type Prostaglandin D Synthase	The solution structure and dynamics of rat Lipocalin-Type Prostaglandin D Synthase	Chenyun Guo, Donghai Lin, Jiafu Liu, Yihe Yao
16418	2010-03-08	Binding_constants: 1 set	Interaction between calcium-free calmodulin and IQ motif of neurogranin studied by nuclear magnetic resonance spectroscopy	Interaction between calcium-free calmodulin and IQ motif of neurogranin studied by nuclear magnetic resonance spectroscopy	David Man, Donghai Lin, Guang Zhu, Jian Wen, Kong Hung Sze, Maili Liu, Yanfang Cui
20078	2010-03-01	Chemical Shifts: 1 set	Solution Structure of Antimicrobial Peptide Hedistin	Conformational and dynamics simulation study of antimicrobial peptide hedistin-heterogeneity of its helix-turn-helix motif.	Guohua Xu, Lin Wang, Maili Liu, Min Wu, Shufen Cao, Xu Zhang, Yanfang Cui
7226	2010-03-04	Chemical Shifts: 1 set	Solution NMR Structure of Conserved protein MTH1368, Northeast Structural Genomics Consortium Target TT821A	Solution NMR Structure of Conserved protein MTH1368, Northeast Structural Genomics Consortium Target TT821A	A Semesi, A Yee, C Arrowsmith, D Parish, D Sukumaran, G Liu, T Szyperski, Y Lin, Y Shen
6736	2005-10-20	Chemical Shifts: 1 set	Backbone 1H, 13C, and 15N Chemical Shift Assignments for Pseudomonas Aeruginosa Protein Pa2021. The Northeast Structural Genomics Consortium Target Pat85.	NMR structure of protein PA2021 from Pseudomonas aeruginosa	Adelinda Yee, B Honig, C Bertonati, Cheryl Arrowsmith, Gaohua Liu, Thomas Szyperski, Yang Shen, Yu-Chieh Lin
6609	2005-09-22	Chemical Shifts: 1 set	Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells	Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells.	Ai-Xin Song, Dong-Hai Lin, Hong-Yu Hu, Shu-Xun Liu, Xue-Tao Cao, Yan-Hong Shi, Yi-Zi Yu, Yong-Ghang Chang, Yong-Guang Gao
6089	2005-05-26	Chemical Shifts: 1 set	1H Chemical Shift Assignments of non-specific Lipid Transfer Protein 1 Isolated from Seeds of Mung Bean	Soluting the molecular structure of mung bean lipid transfer protein 1	Alexandre MJJ Bonvin, C S Cheng, Dharmaraj Samuel, Ku-Feng Lin, Ping-Chiang Lyu, Shang-Te Hsu, Yu-Nan Liu
6023	2004-12-01	Chemical Shifts: 1 set	1H, 15N, and 13C Resonance Assignments of Calmodulin Complexed with the Calmodulin-Binding Domain of Protein Phosphatase 2B	Letter to the Editor: 1H, 15N, and 13C Resonance Assignments of Calmodulin Complexed with the Calmodulin-Binding Domain of calcineurin	Chia-Lin Chyan, Chia-Yen Liu, Chi-jen Lo, Hsien-bin Huang, Jian-Wen Huang, Ta-Hsien Lin, Tzu Chun Tang, Yi-chen Chen
5040	2002-01-23	Chemical Shifts: 1 set	Backbone 1H, 15N, and 13C Resonance Assignments of Inhibitor-1--a Protein Inhibitor of Protein Phosphatase-1	Letter to the Editor: Backbone 1H, 15N, and 13C Resonance Assignments of Inhibitor-1--a Protein Inhibitor of Protein Phosphatase-1	Chen-Kung Liu, Chia-lin Chyan, Fang-Min Lin, Hsien-bin Huang, Hsin-tzu Liu, Meng-Juei Hsieh, Ming-Shi Shiao, Ta-Hsien Lin, Tzu-Chun Tang, Yi-chen Chen
4913	2001-08-08	Chemical Shifts: 1 set	Backbone 1H, 15N, and 13C Resonance Assignments of ARPP-19	Backbone 1H, 15N, and 13C Resonance Assignments of ARPP-19	Angus C Nairn, Atsuko Horiuchi, Chen-Kung Liu, Chia-lin Chyan, Fang-Min Lin, Hsien-bin Huang, Hsin-tzu Liu, Li-huang Tsai, Meng-Juei Hsieh, Ming-Shi Shiao, Paul Greengard, Ta-Hsien Lin, Yi-Cheng Chen