BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 21018

Title: Compstatin 10   PubMed: 22795972

Authors: Qu, Hongchang; Ricklin, Daniel; Bai, Hongjun; Chen, Hui; Reis, Edimara; Maciejewski, Mateusz; Tzekou, Apostolia; DeAngelis, Robert; Resuello, Ranillo; Lupu, Florea; Barlow, Paul; Lambris, John

Citation: Qu, Hongchang; Ricklin, Daniel; Bai, Hongjun; Chen, Hui; Reis, Edimara; Maciejewski, Mateusz; Tzekou, Apostolia; DeAngelis, Robert; Resuello, Ranillo; Lupu, Florea; Barlow, Paul; Lambris, John. "New analogs of the clinical complement inhibitor Compstatin with subnanomolar affinity and enhanced pharmacokinetic properties"  Immunobiology 218, 496-505 (2013).

Assembly members:
Compstatin_10, polymer, 15 residues, Formula weight is not available

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:   Production method: recombinant technology

Entity Sequences (FASTA):
Compstatin_10: XICVXQDWXAHRCIX

Data sets:
Data typeCount
1H chemical shifts102

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1Compstatin_101

Entities:

Entity 1, Compstatin_10 15 residues - Formula weight is not available

1   ACEILECYSVALTRMGLNASPTRPSARALA
2   HISARGCYSILENH2

Samples:

sample_1: Compstatin 10 5 mM; Acetate, [U-100% 2H], 5 mM; H2O 90%; D2O 10%

sample_conditions_1: pH: 6.0; temperature: 288 K

Experiments:

NameSampleSample stateSample conditions
2D DQF-COSYsample_1isotropicsample_conditions_1
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1

Software:

X-PLOR NIH v2.24, Schwieters, Kuszewski, Tjandra and Clore - structure solution

NMR spectrometers:

  • Bruker DRX 800 MHz
  • Bruker DRX 600 MHz

Related Database Links: